Lewis base catalyzed synthesis of multisubstituted 4-sulfonyl-1H-pyrazole involving a novel 1,3-sulfonyl shift.

Abstract

A facile synthesis of highly substituted 4-sulfonyl-1H-pyrazoles from N-propargylic sulfonylhydrazone derivatives has been developed. Allenic sulfonamide formation and 1,3-sulfonyl shift were established to be the critical steps of this transformation.

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